NEVELIA® Collagen Matrix design and crosslinking is the result of years of expertise in the field of collagen.

The extraction procedure and the freeze-drying process structures the collagen into a matrix with optimal hydrophily, pore structure and pore size.

The collagen is then crosslinked to adjust the collagen degradation rate while the dermis is regenerated and therefore optimizes the neodermis quality.


NEVELIA® Bi-Layer Matrix is a sterile medical device consisting of a collagen porous layer to promote and guide regeneration and a reinforced silicone layer acting as a pseudo-epidermis.

This matrix serves as a support for cell infiltration, thus contributes to the natural tissue regeneration process. It is resorbed, becoming a vascularised tissue that is histologically very close to the normal dermis, from 2 to 3 weeks after it is implanted.

NEVELIA® is a three-dimensional porous matrix of stabilised bovine origin Type I Collagen.

NEVELIA® is made of a specific native collagen with a large fibrous proportion to keep cell adhesion signals and mechanical structure to support regeneration.

NEVELIA® is composed of medical-grade silicone elastomer reinforced with a polyester material.

Additional NEVELIA® features are:

  • Optimised pore size3 (average pore size 100 μm) and open-cell structure promoting nutrients flow and fibroblasts migration
  • Crosslinking rate for a balanced absorption / regeneration process
  • No GAG added to keep cells attachment potential

NEVELIA® Dermal Regeneration Process

NeveliaDermalRegenerationProcess-Day 0

Contracted scar
The surgery can be scheduled as soon as the patient is stabilised.

NeveliaDermalRegenerationProcess-Day 1

Excision of the wound
All the dead tissue on and around the graft zone must be removed. For the success of NEVELIA® Bi-layer Matrix, all necrotic and scar tissues must be excised down to the viable tissue.

NeveliaDermalRegenerationProcess-Day 1.1

NEVELIA® Bi-layer Matrix application
NEVELIA® Bi-layer Matrix must be cut to fit the excised wound size exactly. The collagen matrix must be in direct contact with excised wound. The matrix will be fixed in place with surgical staples or sutures.

NeveliaDermalRegenerationProcess-Day 1-21

Neoderm formation
The collagen matrix is quickly colourised by the patients cells and is gradually replaced by an autologous neoderm.

NeveliaDermalRegenerationProcess-Day 21+

Removal of the silicone layer
When the neoderm is formed, the silicone layer is removed. The reconstructed dermis has a distinctive orange-yellow or light yellow colour and may present with slightly reddish areas, sign of good revascularisation.

NeveliaDermalRegenerationProcess-Day 21 2

Harvesting of the graft
A thin split thickness skin graft must be taken, if possible, from an area similar in colour to the reconstructed area. It must be removed with dermatome and may be meshed.

NeveliaDermalRegenerationProcess-Day 21+ 3

Thin split thickness skin graft
The graft is placed on the neoderm and it is fixed with staples or suture.

NeveliaDermalRegenerationProcess-Day 45+

Regenerated skin
Epidermisation. Complete healing of the wound.

NEVELIA® Bi-Layer Matrix Clinical Benefits For Specific Indications

Burns Surgery

  • Waiting donor site availability or extended hours

Chronic Wounds Surgery

  • Good trophicity especially necessary in areas of friction, pressure
  • Adapted to prolonged healing time


  • Good trophicity especially necessary in areas of friction, pressure
  • Adapted to prolonged healing time to combine other treatments

Skin Tumors Surgery

  • Wise choice awaiting anatomopathologist results
  • Facilitates monitoring of cancer recurrence
  • Ease of care for the elderly through faster mobilization